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KMID : 1040620160220030396
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Clinical and Molecular Hepatology
2016 Volume.22 No. 3 p.396 ~ p.399
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A Korean patient with Guillain-Barre syndrome following acute hepatitis E whose cholestasis resolved with steroid therapy
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Ji Sung-Bok
Lee Sang-Soo
Jung Hee-Cheul
Kim Hong-Jun
Kim Hyun-Jin
Kim Tae-Hyo
Jung Woon-Tae
Lee Ok-Jae
Song Dae-Hyun
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Abstract
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Autochthonous hepatitis E virus (HEV) is an emerging pathogen in developed countries, and several cases of acute HEV infection have been reported in South Korea. However, there have been no reports on HEV-associated Guillain-Barre syndrome (GBS) in Korea. We recently experienced the case of a 58-year-old Korean male with acute HEV infection after ingesting raw deer meat. Persistent cholestasis was resolved by the administration of prednisolone. At 2.5 months after the clinical presentation of HEV infection, the patient developed weakness of the lower limbs, and was diagnosed with GBS associated with acute hepatitis E. To our knowledge, this is the second report on supportive steroid therapy for persistent cholestasis due to hepatitis E, and the first report of GBS in a Korean patient with acute HEV infection.
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KEYWORD
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Hepatitis E, Jaundice, Steroid treatment, Guillain-Barre syndrome
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